Seven Reasons Why Home DNA Tests Are Hype

Testing for one’s genetic risk has become increasingly popular in recent years with the mapping of the human genome. Now, you have the opportunity to know if you carry the BRCA genes, or know your risk for Alzheimer’s, other cancers, heart diseases and other diseases and traits, and even one’s genetic ancestry, based on the presence of certain DNA segments in your genome.

Direct-to-Consumer (DTC) DNA testing, also known as personal genome services, allows a person to get his genetic profile just simply by swabbing one’s cheeks or spitting into a test tube and sending the sample back to the genetic testing company. In a few weeks you have your results back in print and at a password-controlled website. Pretty nifty, right?


Actor Ernie Hudson swabs cheek for African Ancestry DNA Test.

Well, this New York Times article writes that the entire DTC industry is more “hype than hope”, and can throw people into the wrong decisions simply by trusting in data that is incomplete and inaccurate.

“It’s important to separate hope from hype,” Dr. Jennifer House, president of the March of Dimes, said at a recent meeting of its national communications advisory council. “Direct-to-consumer genetic testing is a buyer-beware market. Consumers need to be very, very cautious.”

Based on the article, here are seven arguments why the current DTC genetic tests are “a slippery slope”:

1. Most gene tests do not pass the criteria for reliability. (More after the cut.)

2. Many complex diseases have varying degrees of penetrance, so a genetic mutation associated with a disease does not necessarily mean the disease will develop or become as severe. Environment and lifestyle also factor significantly in complex disease, so the chance that a disease would be expressed in a particular person would be unpredictable, and at best an estimate of risks.

3. Lacking a harmful gene that is already known, like a gene linked to breast cancer, does not mean you will not have that disease. Again this is especially true for complex diseases because there are so many genes that could be involved in a disease, and we have not identified all the possible genes and gene-combinations for each disease.

4. Of the 20,000 or more genes in the human genome, Direct-to-Consumer DNA tests only examine a fraction of those genes.

5. There is a relative shortage of counselors who can explain the results, and if need be, guide a consumer through the decision-making process that results after knowing one’s risks and profiles.

6. Privacy and consent for further use of one’s genetic material are vague.  “Your DNA might be sold, shared or used without your consent for testing and research.”

7. No federal law provides oversight of the DTC genetic testing companies.

Image: Newscom

Share This Post:
    • Pingback: Seven Reasons Why Home DNA Tests Are Hype : Genetics & Health … | Dna testing live today()

    • Pingback: Personalized Genetics: DTC Genetic Tests Are Hype « ScienceRoll()

    • Pingback: The World of Genetic Genealogy and DTC Genetic Testing Never Sleeps… » The Genetic Genealogist()

    • Laura

      Nice info to have. I’ve been toying with the idea of doing one of these tests, but hadn’t heard many reviews. Thanks!

    • Stephanie Robin

      Thank you for posting such important information. My name is Stephanie Robin and I am fighting Stage IV Metastatic Breast Cancer and have been sharing my story through my organization, THINK PINK. Each day I am amazed at the number of people I meet who have never heard of the Breast Cancer Gene (BRCA). I am on a mission to spread the word and help as many men and women as possible. Had I known about the BRCA gene, the past five years of my life may not have consisted of many grueling chemotherapy treatments and painful surgeries, let alone the daily fear of my children losing their mommy long before I had a chance to raise them. My THINK PINK team and I have a lofty goal to collect ONE MILLION clicks by Dec. 31, 2009. I invite you and your readers to help me in my mission – a simple click is all it takes!!! Please visit and click to be counted and acknowledge that you now have the information that could save your life. Please share this link with your friends and family. It’s too important not to. Thank you XOXO.

    • Pingback: Picture Of Dna Strand()

    • Pingback: Where Did Mitochondrial Dna Come From()

    • Simon

      Reason 2 & 3 cover genetic testing in general so should not really be used just against this one method.

      • dna testing ancestry

        Interesting thoughts here. I appreciate you taking the time to share them with us all. It’s people like you that make my day.