Skip The Splenda: Artificial Sweeteners Found To Cause Blood Sugar & Insulin Spikes


My, oh my: A new study from the Washington University School of Medicine found it’s possible for popular artificial sweetener sucralose–brand name Splenda–to change the way the body reacts to insulin. This could go a long way to explaining why drinking diet sodas and other artificially sweetened beverages has been somewhat confusingly linked to weight gain.

Despite it’s no-calorie status, sucralose and Splenda are “more than just something sweet that you put into your mouth with no other consequences,” lead researcher M. Yanina Pepino said.

Artificial sweeteners can affect metabolism, even at very low doses, her team concluded.

The study was small: Participants included 17 “severely obese” but non-diabetic individuals who rarely consumed artificial sweeteners prior to the study. Each was given either water or a sucralose sweetened drink, followed by a dose of glucose (regular sugar).

The researchers hoped to determine how the combination of these (“real” and artificial sweeteners) affected people’s insulin and blood sugar levels.

“When study participants drank sucralose, their blood sugar peaked at a higher level than when they drank only water before consuming glucose,” explained Pepino. “Insulin levels also rose about 20 percent higher. So the artificial sweetener was related to an enhanced blood insulin and glucose response.”

In the long-term, elevated insulin response can lead to type-2 diabetes.

So remember: There is no such thing as a consequence-free sweetener, kids. The 20th century was all about trying to trick our bodies with low- and no-calorie diet foods and beverages, and that clearly hasn’t gone so well.

Fake foods were meant to thwart the body’s natural mechanisms, but the body’s natural mechanisms are smarter than Pepsi Co. and Kraft (go figure). Diets don’t work, diet foods don’t work—looks like in the 21st century, we’re just going to have to try eating real food again! It might just be crazy enough to work … 

Elizabeth Nolan Brown, Liz Nolan Brown, Elizabeth Brown, Elizabeth N Brown, health writer, nutritionist, food, nutrition
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    • carter

      I don’t get it…, their blood sugar peaked more after spenda than just drinking water? or their blood sugar spiked more after drinking glucose after splenda than glucose after water? Is a person gpoing to be drinking splenda and glucose at the same time? if you were drinking splenda instead of glucose would the insulin be lower?

      • enbrown

        Their blood pressure spiked more consuming the splenda/sucralose drink together with the glucose drink than it did when they just drank regular water + the glucose drink. In the press release, the researchers mention that they did it this way because people don’t generally consume the artificial sweetener on its own, but with other foods or beverages. And many food and drinks contain glucose-

        I admit the study design seemed a little strange to me, too, though …

      • carter

        what I am guessing is that the splenda/glucose mix is still better than the sugar/glucose mix in terms of blood sugar and insulin,although that comparison is left out – why didn’t they include that measurement?

      • carter

        my thinking – if you are using the splenda as a substitue for sugar you are still better off, but of course if you cut both sugar or splenda out that would be optimal

      • Alex Grossberg


    • Denny Crane

      I am borderline diabetic and sucralose sends me way over the charts with blood sugar issues , worse than regular sugar by far !!!! From multiple personal experiences!