First Whole Genome Scan for OCD Genes

Obsessive compulsive disorder (OCD) is a life-consuming disease that can make it almost impossible to go through the business of everyday life. In the first genome-wide scan for DNA sequences related to OCD, scientists have found six genetic markers on chromosomes 1, 7, 6, and 15 and two markers on chromosome 3, which appear linked to OCD. DNA from 1,008 people from 219 families was analyzed. Further research in these chromosomal regions could lead to the identification of candidate genes that contribute the etiology of OCD.

Dr. Yin Yao Shugart:

OCD is a relative newcomer to these genetic linkage studies, so it’s extremely important to follow up these findings by looking at more families and using more markers to assess the role of gene-environment interactions in OCD. We are also very interested in finding genes underlying the different subtypes of OCD.

The point Dr. Shugart makes about finding genes that underly various subtypes of OCD is very important. Information from genetic testing will help us better define and diagnose diseases, such as autism, that have a wide range of symptoms.

Medical News Today, June 8, 2006

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