Genetics of Pierre Robin Sequence
Angela at Breastfeeding 1-2-3 wrote about the challenges of cleft palate and Pierre Robin Sequence (PRS) today. The story of Lauren and her daughter Charlotte piqued my interest and I found that although the cause of PRS is generally not well understood, there are a few chromosomal loci that are associated:
- 2q24.1-33.3
- 4q32-qter
- 11q21-23.1
- 17q21-24.3
Candidate genes:
- GAD67 on 2q31
- PVRL1 on 11q23-q24
- SOX9 on 17q24.3-q25.1
The Center for Craniofacial Development and Disorders also mentions external factors that affect the development of the jaw, such as crowding in the mother’s uterus due to multiple pregnancy or large fibroids.
Photo credit: MCG Craniofacial Center
Technorati Tags: pierre robin sequence, prs, genetics, genes, dna, diseases, illness, health, cleft palate
Very interesting Hsien! I’m sure Lauren is happy to see more discussion of PRS.
My male baby is born with Pierry Robin Sequence.He is suffering to drink my milk . sometimes Omitting one time daily.He is advised a Surgery aftr 8 months.BAB is weak in increasing weight,.