Mutation in Chromosome 1 Associated with Schizophrenia

UCLA researchers have found that a DNA sequence change in the DISC1 and TRAX genes on chromosome 1 is associated with a ten-fold increase in the risk of schizophrenia, impairments in short- and long-term memory, and other cognitive deficits. It’s hypothesized that the mutation adversely affects “neural scaffolding” and results in a reduction of connectivity between brain cells.

Tyrone D. Cannon, UCLA’s Staglin Family Professor of Psychology, Psychiatry and Human Genetics:

A crime has been committed, and the SWAT team has encircled the neighborhood, which is DISC1. Now we have identified the address and we think we have found the murder weapon. It’s only a matter of time before we have the suspect handcuffed on the lawn.

Violent analogy that neglects to mention if the suspect for schizophrenia is DISC1, then DISC1 is probably a member of the Gene Mafia.

Science Daily, November 16, 2005

NB: The UCLA’s Staglin Family Music Festival Center for the Assessment and Prevention of Prodromal States is looking for individuals ages 12-35 who are experiencing recent changes in their thoughts, feelings and behavior, such as unusual thoughts, distorted or heightened perceptions, ideas of special identity or abilities, suspiciousness, or odd behavior. Other changes may include reduced concentration, reduced energy, depressed mood, sleep disturbance, withdrawal from family or friends, trouble with work or school, anxiety, or irritability. Individuals who are experiencing difficulty functioning and who have a first-degree family member with a psychotic illness, such as schizophrenia, are also encouraged to contact the center. To receive more information, call the center at (310) 206-3466.