I would like to have each family impacted by autism and the asd to contact all federal senators……..to ask them to work a bit harder on getting the vaccines cleaned up, getting the FDA to being honest and forthright……on getting this plague stopped.

Keep me posted.
thanks…………ejhs

A detailed discussion of Geiers’ metabolite values can be found at http://bmartinmd.com/2008/10/geiers-metabolite-values.html.

If you’d like to see scientists study your theory of autism as metabolic disorder perhaps you might lobby for such studies through an organization like the IACC?

“Significantly decreased plasma levels of reduced glutathione (GSH), cysteine, and sulfate were observed among study participants relative to controls”

This shows once again that autism is not solely a neurological “disorder”. It is metabolic, and the metabolic dysfunctions caused are very widespread (they go beyond just the methylation and transulfation pathways).

Yes, yes, I know – this has been reported by the same “quack DAN!” researchers you love to hate. You say GPL and the other labs who do testing for DAN! doctors are faking it.

Fine. You want to prove whether the testing is quack or not? Pony up your own money to do your own independent tests, and then faithfully respond to any criticisms that may be leveled against your study). Tell me why the NImH appears to refuse to even DO a study on chelation, which might settle once and for all the question of whether all the thousands if not tens of thousands of parents who say it works are *all* lying. They say it’s unethical to use DMSA? Then why the hell is it already approved for lead poisoning?

Incidentally, I put the word “disorder” above in quotes for a very good reason. The “neurodiverse movement” DOES have a point – and a very good one. Autistics must be respected and treated like other people, within the limits of what they can and can’t do (as for the ‘can’t do’ part – automatic social processing of sensory stimuli comes to mind). It also appears from the results of the preliminary rTMS experiments being done at the Center For Noninvasive Brain Stimulation (look it up on that hereitical ‘newspaper’ AgeOfAutism..), *as reported by a person with Asperger’s himself* that the ‘gifts’ that are imparted-by/developed-because-of autism are not necessarily lost when ‘missing’ functionality of the brain is restored (hereabovesaid automatic social processing).

Jim Witte

You may be interested in knowing that, to date, I believe there have been four analysis of porphyrin profiles in children with autism with similar results.

Porphyrinuria in childhood autistic disorder: implications for environmental toxicity – 106 autitic participants; not unsurprizingly, children with Aspergers did not show abnormal porphryin profiles.

A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure – 37 autistic participants. Similar findings as far as profiles and differences between autism, Aspergers, and PDD-NOS.

An investigation of porphyrinuria in Australian children with autism – Unknown number of participants, but similar findings to above.

The study referenced above.

HTH

- pD

Yes, pD, Translating Autism has some really good reviews of research and he’s rigorous and reasonable—-

It is after you get autism you seem to have more porphiryin metabolites assocated with mercury so why does that happen.

That’s the big question, isn’t it. A general state of inflammation might be the cause; or the noted differences in glutathione and/or a state of high oxidative stress. There are likely many causes; or many small causes that build up.

Did the researcher look to see if happened with other metals or just the mercury and again where does that mercury seem to come from. I wounder if you could get the same resuts with lead, tin, arsenic or some metal.

Indeed, you can get different porphyrin profiles based on other insults. Of particular interest here is that this isn’t just a case of having more of a particular component, but a specific profile of porphyrins. My (admittedly primitive) understanding is that different insults affect the heme processing chain at different locations; thus the ratio of different porphyrins is different when exposure to mercury versus arsenic, for example.

See:

“Urinary arsenic and porphyrin profile in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII) for two years” –

As a part of 2-year arsenic carcinogenicity study, young female C57BL/6J mice were given drinking water containing 0, 100, 250 and 500 microg/L arsenic as MMA(III)ad libitum. 24 h urine samples were collected at 0, 1, 2, 4, 8 weeks and every 8 weeks for up to 104 weeks. Urinary arsenic speciation and porphyrins were measured using HPLC-ICP-MS and HPLC with fluorescence detection respectively. DMA(V) was a major urinary metabolite detected. Significant dose-response relationship was observed between control and treatment groups after 1, 4, 24, 32, 48, 56, 88, 96 and 104 weeks. The level of uroporphyrin in 250 and 500 microg As/L group is significantly different from the control group after 4, 8, 16, 32, 56, 72, 80, 96 and 104 weeks.

Or,

“Porphyrins as the early biomarkers for arsenic exposure of human”

Analytical data showed that urinary uroporphyrin-III and coproporphyrin-III were significantly elevated in arsenic-exposed group compared with those in control group, while urinary coproporphyrin-I was not significantly higher in arsenic-exposed group than that in control group.

There are many, many others. Note that they are paying attention not just to an increase, but which particular porphyrins are being increased. This speaks towards where the heme pathway is being disrupted, and thus, somewhat of a marker of what is causing the problem.

It turns out, that the specific profile many children with autism have corresponds closely to those that have previously been identified with mercury exposure. That doesn’t mean that ONLY mercury could cause such a profile, just that there is a match. Perhaps there is another insult, or combination of insults, which could cause a backup in the same location.

- pD

This isn’t conclusive evidence for this correlation; the sample size simply isn’t big enough–there’s too much uncertainty.

At the most, this is a preliminary study that can conclude no more than “This topic is a worthwhile target for further research.”