Comments on: New Study on the Genetic Causes of Autism http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/ Family, Health, Home and Lifestyles Wed, 09 Dec 2009 07:55:54 -0500 http://wordpress.org/?v=2.8.4 hourly 1 By: Autism Genes: Approaching a New Neurobiology http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-556952 Autism Genes: Approaching a New Neurobiology Tue, 24 Jun 2008 22:45:33 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-556952 [...] hesitant at first to write about what seemed such a specialized topic. But the more I read about genetic research and wrote about it (here, here, here and here, for example) , the more intrigued I became (and the [...] [...] hesitant at first to write about what seemed such a specialized topic. But the more I read about genetic research and wrote about it (here, here, here and here, for example) , the more intrigued I became (and the [...]

]]> By: Legal Standards, Science, and the Cause of Autism http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-554685 Legal Standards, Science, and the Cause of Autism Thu, 27 Mar 2008 05:37:19 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-554685 [...] and more evidence refuting a link between thimerosal and rising autism rates, and more and more studies pointing to a complex web of genetic factors in autism. And yet, again and again, the [...] [...] and more evidence refuting a link between thimerosal and rising autism rates, and more and more studies pointing to a complex web of genetic factors in autism. And yet, again and again, the [...]

]]> By: Like Father, Like Son: Chromosome 16 and susceptibility to autism http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-544619 Like Father, Like Son: Chromosome 16 and susceptibility to autism Thu, 10 Jan 2008 06:37:09 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-544619 [...] a year ago, a study was published in the February 2007 Nature Genetics suggesting that 90 percent of autism may have a genetic basis. Either a deletion or a duplication of a section of chromosome 16 seems to contribute strongly to [...] [...] a year ago, a study was published in the February 2007 Nature Genetics suggesting that 90 percent of autism may have a genetic basis. Either a deletion or a duplication of a section of chromosome 16 seems to contribute strongly to [...]

]]> By: Robert C. Parker http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-538628 Robert C. Parker Mon, 27 Aug 2007 13:11:33 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-538628 It is time to stand up and face the truth! My son was diagnosed march '07, I had asked the Nuerologist what causes this, Genes, he said, not mine or my wifes genes, my sons genes? He also stated there are no alternative ways to heal or cure him, we were told to start him in all the therapie$, change the way we parent and move clo$er to the facility where he is, (we live in a rural 20 acre area)...Thank the creator I didn't stop there, we have since discovered many children being cured through alternative medicines and most important the diet, which brings me back to the "Truth", my son was injured by his vaccinations, this is what caused his regression, it is time to admit and accept this so we can go forward and start helping people affected by this both physically, and monetarily. There is much more to be said and done! I'll leave it at that for now. It is time to stand up and face the truth! My son was diagnosed march ‘07, I had asked the Nuerologist what causes this, Genes, he said, not mine or my wifes genes, my sons genes? He also stated there are no alternative ways to heal or cure him, we were told to start him in all the therapie$, change the way we parent and move clo$er to the facility where he is, (we live in a rural 20 acre area)…Thank the creator I didn’t stop there, we have since discovered many children being cured through alternative medicines and most important the diet, which brings me back to the “Truth”, my son was injured by his vaccinations, this is what caused his regression, it is time to admit and accept this so we can go forward and start helping people affected by this both physically, and monetarily.
There is much more to be said and done! I’ll leave it at that for now.

]]> By: Robert C. Parker http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-538627 Robert C. Parker Mon, 27 Aug 2007 13:09:44 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-538627 It is time to stand up and face the truth! My son was diagnosed march '07, I had asked the Nuerologist what causes this, Genes, he said, not mine or my wifes genes, my sons genes? He also stated there are no alternative ways to heal or cure him, we were told to start him in all the therapie$, change the way we parent and move clo$er to the facility where he is, (we live in a rural 20 acre area)...Thank the creator I didn't stop there, we have since discovered may children being cured through alternative medicines and most important the diet, which brings me back to the "Truth", my son was injured by his vaccinations, this is what caused his regression, it is time to admit and accept this so we can go forward and start helping peoplee affected by this both physically, and monetarily. There is much more to be said and done! I'll leave it at that for now. It is time to stand up and face the truth! My son was diagnosed march ‘07, I had asked the Nuerologist what causes this, Genes, he said, not mine or my wifes genes, my sons genes? He also stated there are no alternative ways to heal or cure him, we were told to start him in all the therapie$, change the way we parent and move clo$er to the facility where he is, (we live in a rural 20 acre area)…Thank the creator I didn’t stop there, we have since discovered may children being cured through alternative medicines and most important the diet, which brings me back to the “Truth”, my son was injured by his vaccinations, this is what caused his regression, it is time to admit and accept this so we can go forward and start helping peoplee affected by this both physically, and monetarily.
There is much more to be said and done! I’ll leave it at that for now.

]]> By: On Autism Genetics http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-538617 On Autism Genetics Mon, 27 Aug 2007 11:41:32 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-538617 [...] first genetics study was conducted by the AGP and involved over 1,000 families. Entitled Mapping autism risk loci using [...] [...] first genetics study was conducted by the AGP and involved over 1,000 families. Entitled Mapping autism risk loci using [...]

]]> By: Gina http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-537176 Gina Mon, 06 Aug 2007 05:01:29 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-537176 RE: the Leprosy/Autism discussion. Have any of you investigated the recent work done in Mendelian Susceptibility to Mycobacteria? I personally, think that a combination of this genetic disorder ( which is also a spectrum disorder as the genes can be really badly messed up, medium messed up or only slightly, resulting in different outcomes) combined with encountering mycobacteria in the pre-natal womb enviroment (extra-pulmonary TB is often transmitted in the womb) or afterwards is at the root of what causes Autism. It would explain its increase as mycobacterial infections of all types are on the rise all over the world and it would also provide a NEW insight into the vaccine problem. Apparently, in some populations, like those who may have genetic pre-disposition to Mendelian Mycobacteria Susceptibility, when they get a vaccine, their circulating levels of immune system protecting gamma inteferon drop, either temporarily or sometimes permanently (thus causing the repeated infections that some autistics face again and again), and during this period of deactivated gamma interferon caused by NUMEROUS vaccines, a child who had a appeared to be developing normally, could contract the mycobacteria (other other viruses or mycrobes) and thus the austism would begin to show. You can check out the interferon gamma problem by googling vaccines and gamma interferon disruption. Hope this helps, Gina RE: the Leprosy/Autism discussion. Have any of you investigated the recent work done in Mendelian Susceptibility to Mycobacteria? I personally, think that a combination of this genetic disorder ( which is also a spectrum disorder as the genes can be really badly messed up, medium messed up or only slightly, resulting in different outcomes) combined with encountering mycobacteria in the pre-natal womb enviroment (extra-pulmonary TB is often transmitted in the womb) or afterwards is at the root of what causes Autism. It would explain its increase as mycobacterial infections of all types are on the rise all over the world and it would also provide a NEW insight into the vaccine problem. Apparently, in some populations, like those who may have genetic pre-disposition to Mendelian Mycobacteria Susceptibility, when they get a vaccine, their circulating levels of immune system protecting gamma inteferon drop, either temporarily or sometimes permanently (thus causing the repeated infections that some autistics face again and again), and during this period of deactivated gamma interferon caused by NUMEROUS vaccines, a child who had a appeared to be developing normally, could contract the mycobacteria (other other viruses or mycrobes) and thus the austism would begin to show. You can check out the interferon gamma problem by googling vaccines and gamma interferon disruption.

Hope this helps,
Gina

]]> By: RA Jensen http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-534980 RA Jensen Fri, 25 May 2007 18:48:40 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-534980 What is 90% heritable? Autism per se or autism susceptability genes that require an environmental insult, the 'second hit' theory? The polygenic theorists have always claimed that autism is 90% heritable based on twin studies, clustering within families and a higher sib risk ratio than is found in the general population. It is useful to compare the genetic component of autism to the genetic component of other conditions that are more clearly understood. The cause of leprosy, exposure to myobacterium Laprae, has been known for over a hundred years. What is not known is that the magnitude of the genetic component found in leprosy mirrors the genetic data in autism. Twin studies in India demonstrate the magnitude of the genetic component in leprosy with high concordance rates reported in MZ twins ( 60 - 85% ) and a rapid falloff in concordance reported in DZ twins ( 5 - 20% ). Leprosy clusters withon families and leprosy multiplex families have recruited and genome wide scans searching for leprosy susceptability genes have been underway for a decade. There are as many candidate genes reported in leprosy susceptability as there are in autism. The sib risk ratio in leprosy is 2.4, the same ratio reported in many autism family linkage studies. http://www.nature.com/ng/journal/v27/n4/full/ng0401_439.html Ther is also the same unexplained high male to female ratio reporte in leprosy population studies as has been consistently reported in autism research http://www.scielosp.org/scielo.php?pid=S0042-96862001000400007&script=sci_arttext "Between 1949 and 1998 a total of 474 774 leprosy cases were detected in China; 75.2% were males and 24.8% were females (male:female = 3:1)" I don't question the data in autism genetic research, it is the interpretation of the data that can be questioned What is 90% heritable? Autism per se or autism susceptability genes that require an environmental insult, the ’second hit’ theory? The polygenic theorists have always claimed that autism is 90% heritable based on twin studies, clustering within families and a higher sib risk ratio than is found in the general population.

It is useful to compare the genetic component of autism to the genetic component of other conditions that are more clearly understood.

The cause of leprosy, exposure to myobacterium Laprae, has been known for over a hundred years. What is not known is that the magnitude of the genetic component found in leprosy mirrors the genetic data in autism.

Twin studies in India demonstrate the magnitude of the genetic component in leprosy with high concordance rates reported in MZ twins ( 60 – 85% ) and a rapid falloff in concordance reported in DZ twins ( 5 – 20% ). Leprosy clusters withon families and leprosy multiplex families have recruited and genome wide scans searching for leprosy susceptability genes have been underway for a decade. There are as many candidate genes reported in leprosy susceptability as there are in autism. The sib risk ratio in leprosy is 2.4, the same ratio reported in many autism family linkage studies.

http://www.nature.com/ng/journal/v27/n4/full/ng0401_439.html

Ther is also the same unexplained high male to female ratio reporte in leprosy population studies as has been consistently reported in autism research

http://www.scielosp.org/scielo.php?pid=S0042-96862001000400007&script=sci_arttext

“Between 1949 and 1998 a total of 474 774 leprosy cases were detected in China; 75.2% were males and 24.8% were females (male:female = 3:1)”

I don’t question the data in autism genetic research, it is the interpretation of the data that can be questioned

]]> By: genetics technology » Blog Archive » Why cats are finicky eaters - Science - MSNBC.com http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-534242 genetics technology » Blog Archive » Why cats are finicky eaters - Science - MSNBC.com Fri, 18 May 2007 21:49:02 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-534242 [...] A study on the most extensive findings so far on the genetics of autism by Scherer and researchers from a consortium of 19 nations appears today in Nature Genetics. Entitled Mapping autism risk loci using genetic linkage and chromosonal … …more [...] [...] A study on the most extensive findings so far on the genetics of autism by Scherer and researchers from a consortium of 19 nations appears today in Nature Genetics. Entitled Mapping autism risk loci using genetic linkage and chromosonal … …more [...]

]]> By: Kristina Chew, PhD http://www.blisstree.com/articles/new-study-on-the-genetic-causes-of-autism/comment-page-1/#comment-530783 Kristina Chew, PhD Thu, 22 Feb 2007 19:16:06 +0000 http://www.autismvox.com/new-study-on-the-genetic-causes-of-autism/#comment-530783 I will consult the article and get back to you---- I will consult the article and get back to you—-

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