Comments on: Of Mice and Noise http://www.blisstree.com/articles/of-mice-and-noise/ Family, Health, Home and Lifestyles Wed, 23 Dec 2009 14:53:28 -0500 http://wordpress.org/?v=2.8.4 hourly 1 By: RAJ http://www.blisstree.com/articles/of-mice-and-noise/comment-page-1/#comment-560934 RAJ Thu, 28 Aug 2008 13:54:21 +0000 http://www.autismvox.com/of-mice-and-noise/#comment-560934 PS I forgot to post the results of the first study that showed the increase risk or 'autism' associated with prenatal exposure to Valproate Acid: http://www.ncbi.nlm.nih.gov/pubmed/16108456? PS I forgot to post the results of the first study that showed the increase risk or ‘autism’ associated with prenatal exposure to Valproate Acid:

http://www.ncbi.nlm.nih.gov/pubmed/16108456?

]]> By: RAJ http://www.blisstree.com/articles/of-mice-and-noise/comment-page-1/#comment-563091 RAJ Thu, 28 Aug 2008 13:48:11 +0000 http://www.autismvox.com/of-mice-and-noise/#comment-563091 "thanks for noting the other study, RAJ—–what would be a “human model” of various mouse diseases" Since there are many 'causes' of autism (a loosely defined condition) there is likely no one mouse model that would apply to all cases. My interest is in the subgroup associated with an anti-convulsant syndrome since my daughter was exposed in utero to an anti-convulsant. Prenatal exposure to the anti-convulsant Valproate Acid has been strongly linked to increased risk for autism and the finding has been replicated. Autism autopsy reports have consistently shown abnormalities in development of the hippocampus and cerebellum and the same finding is also replicated in VPA exposed mice: http://www.ncbi.nlm.nih.gov/pubmed/18316065? A recent study has shown that VPA induced 'autistic' mice have shown remarkeable improvement with environmental enrichment. Many of the mice have reversed the behavioral impairments through various interventions and that finding can be related to the therapies that have been found to be most effect in the treatment of autism, eg early intervention, speech and language therapy, occupational therapy and if started early enough can reverse to varying degrees the behavioral problems associated with 'autism'. Of course, the most important finding related to Fetal Anticonvulsant Syndrome is prevention. “thanks for noting the other study, RAJ—–what would be a “human model” of various mouse diseases”

Since there are many ’causes’ of autism (a loosely defined condition) there is likely no one mouse model that would apply to all cases. My interest is in the subgroup associated with an anti-convulsant syndrome since my daughter was exposed in utero to an anti-convulsant.

Prenatal exposure to the anti-convulsant Valproate Acid has been strongly linked to increased risk for autism and the finding has been replicated.

Autism autopsy reports have consistently shown abnormalities in development of the hippocampus and cerebellum and the same finding is also replicated in VPA exposed mice:

http://www.ncbi.nlm.nih.gov/pubmed/18316065?

A recent study has shown that VPA induced ‘autistic’ mice have shown remarkeable improvement with environmental enrichment. Many of the mice have reversed the behavioral impairments through various interventions and that finding can be related to the therapies that have been found to be most effect in the treatment of autism, eg early intervention, speech and language therapy, occupational therapy and if started early enough can reverse to varying degrees the behavioral problems associated with ‘autism’.

Of course, the most important finding related to Fetal Anticonvulsant Syndrome is prevention.

]]> By: Say It Once, Say It Twice http://www.blisstree.com/articles/of-mice-and-noise/comment-page-1/#comment-560896 Say It Once, Say It Twice Thu, 28 Aug 2008 07:58:24 +0000 http://www.autismvox.com/of-mice-and-noise/#comment-560896 [...] I wrote about a study on ultrasonic vocalizations in BTBR mice, who are one “mouse model” of autism. The August 27th Science Daily [...] [...] I wrote about a study on ultrasonic vocalizations in BTBR mice, who are one “mouse model” of autism. The August 27th Science Daily [...]

]]> By: Emily http://www.blisstree.com/articles/of-mice-and-noise/comment-page-1/#comment-563051 Emily Thu, 28 Aug 2008 00:10:36 +0000 http://www.autismvox.com/of-mice-and-noise/#comment-563051 Two things, too. One is really not related but just kind of weird: I have a friend who works with singing mice. Very strange. Second, both TH and Little were MAJOR grunters as infants. All night. Would never stop. And it was GRUNTING...prolonged and loud and we thought it must hurt somehow to do it so much, so gutturally. Very strange. TH, as I've mentioned before, is big on vocalizing, but he doesn't grunt as much as he squeals, squeaks, says, "eeeeeeeeeeee!" etc. His vocalizations are really all very high pitched. Two things, too. One is really not related but just kind of weird: I have a friend who works with singing mice. Very strange.

Second, both TH and Little were MAJOR grunters as infants. All night. Would never stop. And it was GRUNTING…prolonged and loud and we thought it must hurt somehow to do it so much, so gutturally. Very strange.

TH, as I’ve mentioned before, is big on vocalizing, but he doesn’t grunt as much as he squeals, squeaks, says, “eeeeeeeeeeee!” etc. His vocalizations are really all very high pitched.

]]> By: Kristina Chew, PhD http://www.blisstree.com/articles/of-mice-and-noise/comment-page-1/#comment-558985 Kristina Chew, PhD Wed, 27 Aug 2008 20:34:48 +0000 http://www.autismvox.com/of-mice-and-noise/#comment-558985 thanks for noting the other study, RAJ-----what would be a "human model" of various mouse diseases..... thanks for noting the other study, RAJ—–what would be a “human model” of various mouse diseases…..

]]> By: Club 166 http://www.blisstree.com/articles/of-mice-and-noise/comment-page-1/#comment-563001 Club 166 Wed, 27 Aug 2008 20:12:07 +0000 http://www.autismvox.com/of-mice-and-noise/#comment-563001 Two things. First, with the diagnostic criteria being as variable as they are in humans, I find trying to identify a "mouse model" of autism to be laughable. Second, Buddy Boy grunted so much when he was born that for some time I thought that he might have sleep apnea, and slept by his bedside with my stethoscope. Like your Charlie, he still grunts (and has his chorus of other unique vocalizations). Joe Two things.

First, with the diagnostic criteria being as variable as they are in humans, I find trying to identify a “mouse model” of autism to be laughable.

Second, Buddy Boy grunted so much when he was born that for some time I thought that he might have sleep apnea, and slept by his bedside with my stethoscope. Like your Charlie, he still grunts (and has his chorus of other unique vocalizations).

Joe

]]> By: RAJ http://www.blisstree.com/articles/of-mice-and-noise/comment-page-1/#comment-562943 RAJ Wed, 27 Aug 2008 16:43:26 +0000 http://www.autismvox.com/of-mice-and-noise/#comment-562943 There are many mouse models for autism. Prenatal exposure to valproic acid (an anti-convulsant) has been strongly assoicated with autism in humans. Mouse studies have also found that behavioral impairments resembling autism, similar brain damage in the mice are also found in autism autopsy studies. A new report published last month also replicated those arlier results. A new finding is that male mice are more susceptable to adverse outcomes associated with prenatal exposure to valperoate acid.... there is a 3:1 or 4:1 male female ratio in autism. http://www.ncbi.nlm.nih.gov/pubmed/18396377? There are many mouse models for autism. Prenatal exposure to valproic acid (an anti-convulsant) has been strongly assoicated with autism in humans. Mouse studies have also found that behavioral impairments resembling autism, similar brain damage in the mice are also found in autism autopsy studies.

A new report published last month also replicated those arlier results. A new finding is that male mice are more susceptable to adverse outcomes associated with prenatal exposure to valperoate acid…. there is a 3:1 or 4:1 male female ratio in autism.

http://www.ncbi.nlm.nih.gov/pubmed/18396377?

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