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	<title>Comments on: Of Mice, Synapses, and Autism</title>
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	<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/</link>
	<description>Family, Health, Home and Lifestyles</description>
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		<title>By: More on CNTNAP2, an Autism Susceptibility Gene, and Parent of Origin Bias</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-545410</link>
		<dc:creator>More on CNTNAP2, an Autism Susceptibility Gene, and Parent of Origin Bias</dc:creator>
		<pubDate>Sat, 12 Jan 2008 06:50:01 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-545410</guid>
		<description>[...] when the gene with that variation is inherited from the mother. CNTNAP2 is a member of the neurexin superfamily and is, as noted in the January 11th Science Daily, &#8220;makes a protein that enables [...]</description>
		<content:encoded><![CDATA[<p>[...] when the gene with that variation is inherited from the mother. CNTNAP2 is a member of the neurexin superfamily and is, as noted in the January 11th Science Daily, &#8220;makes a protein that enables [...]</p>
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		<title>By: Zaecus</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-542833</link>
		<dc:creator>Zaecus</dc:creator>
		<pubDate>Sat, 22 Dec 2007 02:59:27 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-542833</guid>
		<description>Ah, Texas.  I live in a state where an amazing amount of funding is being thrown at controlling the undesirable behaviors of, or simply eradicating, those like me, but the state organizations that are supposed to be their to help me won&#039;t help with legal matters, suggesting I get a lawyer on my own, the local ASA chapter ignores my email, and the assistance counselor just stopped talking to me completely.</description>
		<content:encoded><![CDATA[<p>Ah, Texas.  I live in a state where an amazing amount of funding is being thrown at controlling the undesirable behaviors of, or simply eradicating, those like me, but the state organizations that are supposed to be their to help me won&#8217;t help with legal matters, suggesting I get a lawyer on my own, the local ASA chapter ignores my email, and the assistance counselor just stopped talking to me completely.</p>
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		<title>By: RAJ</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-544836</link>
		<dc:creator>RAJ</dc:creator>
		<pubDate>Tue, 11 Dec 2007 19:24:53 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-544836</guid>
		<description>Synapse disruptions have also been observed in mice prenatally exposed to the anti-convulsant Sodium Valproate, one of the few known environmental causes of autism and other developmental disorders by interrupting normal brain development and synapse connections.

http://cercor.oxfordjournals.org/cgi/content/abstract/bhm117v1

Th original article makes the genetic claim based on two sisters from the same family that were found to have the neurologin anomaly..... Out of 3,000 persons whose DNA is in the AGRE data base. The anomaly was not found in other large samples of multiple incidence familiesb but has been found in mentally retarded and schizophrenic people.

The congenital anti-convulsant syndrome associated with autism has been accepted as conclusive by both genetic researchers and environmental researchers.</description>
		<content:encoded><![CDATA[<p>Synapse disruptions have also been observed in mice prenatally exposed to the anti-convulsant Sodium Valproate, one of the few known environmental causes of autism and other developmental disorders by interrupting normal brain development and synapse connections.</p>
<p><a href="http://cercor.oxfordjournals.org/cgi/content/abstract/bhm117v1" rel="nofollow">http://cercor.oxfordjournals.org/cgi/content/abstract/bhm117v1</a></p>
<p>Th original article makes the genetic claim based on two sisters from the same family that were found to have the neurologin anomaly&#8230;.. Out of 3,000 persons whose DNA is in the AGRE data base. The anomaly was not found in other large samples of multiple incidence familiesb but has been found in mentally retarded and schizophrenic people.</p>
<p>The congenital anti-convulsant syndrome associated with autism has been accepted as conclusive by both genetic researchers and environmental researchers.</p>
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		<title>By: RAJ</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-543925</link>
		<dc:creator>RAJ</dc:creator>
		<pubDate>Tue, 11 Dec 2007 19:23:15 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-543925</guid>
		<description>Synapse disruptions have also been observed in mice prenatally exposed to the anti-convulsant Sodium Valproate, one of the few known environmental causes of autism and other developmental disorders by interrupting normal brain development and synapse connections.

hattp://cercor.oxfordjournals.org/cgi/content/abstract/bhm117v1

Th original article makes the genetic claim based on two sisters from the same family that were found to have the neurologin anomaly..... Out of 3,000 persons whose DNA is in the AGRE data base. The anomaly was not found in other large samples of multiple incidence familiesb but has been found in mentally retarded and schizophrenic people.

The congenital anti-convulsant syndrome associated with autism has been accepted as conclusive by both genetic researchers and environmental researchers.</description>
		<content:encoded><![CDATA[<p>Synapse disruptions have also been observed in mice prenatally exposed to the anti-convulsant Sodium Valproate, one of the few known environmental causes of autism and other developmental disorders by interrupting normal brain development and synapse connections.</p>
<p>hattp://cercor.oxfordjournals.org/cgi/content/abstract/bhm117v1</p>
<p>Th original article makes the genetic claim based on two sisters from the same family that were found to have the neurologin anomaly&#8230;.. Out of 3,000 persons whose DNA is in the AGRE data base. The anomaly was not found in other large samples of multiple incidence familiesb but has been found in mentally retarded and schizophrenic people.</p>
<p>The congenital anti-convulsant syndrome associated with autism has been accepted as conclusive by both genetic researchers and environmental researchers.</p>
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		<title>By: Emily</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-544544</link>
		<dc:creator>Emily</dc:creator>
		<pubDate>Tue, 11 Dec 2007 01:01:37 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-544544</guid>
		<description>Have any of you heard of using the gene deletion in William&#039;s syndrome as a model for autism in mice?</description>
		<content:encoded><![CDATA[<p>Have any of you heard of using the gene deletion in William&#8217;s syndrome as a model for autism in mice?</p>
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		<title>By: Patrick</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-547482</link>
		<dc:creator>Patrick</dc:creator>
		<pubDate>Tue, 11 Dec 2007 00:03:34 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-547482</guid>
		<description>I too have problems with folks saying they have modeled human autism in mice, as they haven&#039;t even defined what human autism is completely yet, or we would already have someone&#039;s disgusting genetic tests already approved and verified.

/start sarcasm
I think it is also sensationalising themselves in their own mind to say that this is the first ever model.  We have been reading about autistic mice for years, just because they weren&#039;t nlgn3 knockouts didn&#039;t mean they were inferior/lacking of the love and support all the other AutMice have gotten.

I think we need genetically engineered mice testing for curebiesm and politicians and lawyers too, let&#039;s not diskriminate too much.

/end sarcasm</description>
		<content:encoded><![CDATA[<p>I too have problems with folks saying they have modeled human autism in mice, as they haven&#8217;t even defined what human autism is completely yet, or we would already have someone&#8217;s disgusting genetic tests already approved and verified.</p>
<p>/start sarcasm<br />
I think it is also sensationalising themselves in their own mind to say that this is the first ever model.  We have been reading about autistic mice for years, just because they weren&#8217;t nlgn3 knockouts didn&#8217;t mean they were inferior/lacking of the love and support all the other AutMice have gotten.</p>
<p>I think we need genetically engineered mice testing for curebiesm and politicians and lawyers too, let&#8217;s not diskriminate too much.</p>
<p>/end sarcasm</p>
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		<title>By: Kristina Chew, PhD</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-544447</link>
		<dc:creator>Kristina Chew, PhD</dc:creator>
		<pubDate>Mon, 10 Dec 2007 20:49:26 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-544447</guid>
		<description>Charlie too does not seem bothered by loud noises---it&#039;s the high-pitched ones (sometimes my voice; have to watch it) that can irk him.

The latest spin on these findings is that autism can be &quot;&lt;a href=&quot;http://www.craegmoor.co.uk/news/industry/18388223/autism_can_be_induced_in_mice.aspx&quot;&gt;induced&lt;/a&gt;&quot; in mice.</description>
		<content:encoded><![CDATA[<p>Charlie too does not seem bothered by loud noises&#8212;it&#8217;s the high-pitched ones (sometimes my voice; have to watch it) that can irk him.</p>
<p>The latest spin on these findings is that autism can be &#8220;<a href="http://www.craegmoor.co.uk/news/industry/18388223/autism_can_be_induced_in_mice.aspx">induced</a>&#8221; in mice.</p>
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		<title>By: Leila</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-544410</link>
		<dc:creator>Leila</dc:creator>
		<pubDate>Mon, 10 Dec 2007 19:23:36 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-544410</guid>
		<description>Hi Ralph, in my son&#039;s case I don&#039;t think it&#039;s mostly a sensory issue that makes it harder for him to participate or understand social situations and rules. I think it is more a matter of not being aware of other people&#039;s social expectations and &quot;not seeing the point&quot;, or the use of behaving as expected/demanded. He is affectionate and loves to socialize, but he does it in his own terms, or in the ways he had to be taught (greetings, taking turns in games, answering to questions, etc).

I agree that autism is very heterogenous. While for many kids the anxiety and sensory problems are the main struggles, I see my autistic child as a very easy-going person whose main challenge is following instructions that do not agree with his own agenda; and of course learning language and social rules has been really difficult for him. But I can take him anywhere that&#039;s loud, crowded, with blinking lights, he won&#039;t care... He doesn&#039;t mind the feel of different clothes, or grass, sand, mud, bark or water; he doesn&#039;t need a schedule or previous warnings of where we&#039;re going, he pretty much goes with the flow.

I also think that the mice study should not be dismissed, most research cannot encompass the total range of causes and symptoms of autism.  Current knowldedge says it involves multiple genes, and those scientists are manipulating only one of the genes that might be associated with the disorder. The fact that the social skills and space/visual skills are affected by that same gene is a very insteresting discovery.</description>
		<content:encoded><![CDATA[<p>Hi Ralph, in my son&#8217;s case I don&#8217;t think it&#8217;s mostly a sensory issue that makes it harder for him to participate or understand social situations and rules. I think it is more a matter of not being aware of other people&#8217;s social expectations and &#8220;not seeing the point&#8221;, or the use of behaving as expected/demanded. He is affectionate and loves to socialize, but he does it in his own terms, or in the ways he had to be taught (greetings, taking turns in games, answering to questions, etc).</p>
<p>I agree that autism is very heterogenous. While for many kids the anxiety and sensory problems are the main struggles, I see my autistic child as a very easy-going person whose main challenge is following instructions that do not agree with his own agenda; and of course learning language and social rules has been really difficult for him. But I can take him anywhere that&#8217;s loud, crowded, with blinking lights, he won&#8217;t care&#8230; He doesn&#8217;t mind the feel of different clothes, or grass, sand, mud, bark or water; he doesn&#8217;t need a schedule or previous warnings of where we&#8217;re going, he pretty much goes with the flow.</p>
<p>I also think that the mice study should not be dismissed, most research cannot encompass the total range of causes and symptoms of autism.  Current knowldedge says it involves multiple genes, and those scientists are manipulating only one of the genes that might be associated with the disorder. The fact that the social skills and space/visual skills are affected by that same gene is a very insteresting discovery.</p>
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		<title>By: Kristina Chew, PhD</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-544015</link>
		<dc:creator>Kristina Chew, PhD</dc:creator>
		<pubDate>Mon, 10 Dec 2007 02:12:44 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-544015</guid>
		<description>We&#039;ll (I, at least!) will be glad to start deconstructing the term &quot;autie&quot; for you; it might further be helpful to consider some works of &lt;a href=&quot;http://64.233.169.104/search?q=cache:PRH8Yr-g19oJ:case.edu/affil/sce/Texts_2005/Autism%2520and%2520Representation%2520Rose.doc+autiebiography+irene+rose&amp;hl=en&amp;ct=clnk&amp;cd=1&amp;gl=us&amp;client=safari&quot;&gt;autiebiography&lt;/a&gt;.</description>
		<content:encoded><![CDATA[<p>We&#8217;ll (I, at least!) will be glad to start deconstructing the term &#8220;autie&#8221; for you; it might further be helpful to consider some works of <a href="http://64.233.169.104/search?q=cache:PRH8Yr-g19oJ:case.edu/affil/sce/Texts_2005/Autism%2520and%2520Representation%2520Rose.doc+autiebiography+irene+rose&#038;hl=en&#038;ct=clnk&#038;cd=1&#038;gl=us&#038;client=safari">autiebiography</a>.</p>
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		<title>By: Harold L Doherty</title>
		<link>http://www.blisstree.com/articles/of-mice-synapses-and-autism/comment-page-1/#comment-544086</link>
		<dc:creator>Harold L Doherty</dc:creator>
		<pubDate>Mon, 10 Dec 2007 01:41:56 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/of-mice-synapses-and-autism/#comment-544086</guid>
		<description>Mr. Saverese

The researchers involved in the study did not suggest that a study involving mice is final and conclusive , far from it. But your superficial rejection of serious research is interesting. Mottron, Gernsbacher and Dawson are engaged in research to substantiate their ideological  views about autism which you share.  They offer little research outside that limited focus.  

Ask the auties? OK, I will ask my son, who has Autism Disorder, who speaks at a very rudimentary, concrete level and who has a limited understanding of the world. What will my son the &quot;autie&quot; say? Of course he has Autism Disorder, actual Autism Disorder, perhaps your were referring to someone on the spectrum of pervasive developmental disorders diagnosed with Aspergers or some other similar but distinct condition?

By the way, since you and Ms Chew are very word sensitive, highly educated Ph D&#039;s with literary backgrounds I have to say, as the father of an autistic 12 year old boy with Autism Disorder, that I find the term &quot;Autie&quot; offensive, denigrating and stereotypical.</description>
		<content:encoded><![CDATA[<p>Mr. Saverese</p>
<p>The researchers involved in the study did not suggest that a study involving mice is final and conclusive , far from it. But your superficial rejection of serious research is interesting. Mottron, Gernsbacher and Dawson are engaged in research to substantiate their ideological  views about autism which you share.  They offer little research outside that limited focus.  </p>
<p>Ask the auties? OK, I will ask my son, who has Autism Disorder, who speaks at a very rudimentary, concrete level and who has a limited understanding of the world. What will my son the &#8220;autie&#8221; say? Of course he has Autism Disorder, actual Autism Disorder, perhaps your were referring to someone on the spectrum of pervasive developmental disorders diagnosed with Aspergers or some other similar but distinct condition?</p>
<p>By the way, since you and Ms Chew are very word sensitive, highly educated Ph D&#8217;s with literary backgrounds I have to say, as the father of an autistic 12 year old boy with Autism Disorder, that I find the term &#8220;Autie&#8221; offensive, denigrating and stereotypical.</p>
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