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	<title>Comments on: Sporadic and Heritable Autism</title>
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	<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/</link>
	<description>Family, Health, Home and Lifestyles</description>
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		<title>By: sham</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-560899</link>
		<dc:creator>sham</dc:creator>
		<pubDate>Fri, 12 Sep 2008 09:04:44 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-560899</guid>
		<description>My Brother has two daughters. One contracted memingitis soon after birth and suffered mental retardation as a result. The second is currently being &#039;tested&#039; for Autism. There are no other family members that show signs of Autism in our side of the family, however, my brothers wife has family that have been diagnosed as such. 

My wife and I are currently considering having children, whats the probability that we could have an autistic child? Is there any way to test for it? I may be being paranoid but its a concern I have. Any advice would be appreciated.</description>
		<content:encoded><![CDATA[<p>My Brother has two daughters. One contracted memingitis soon after birth and suffered mental retardation as a result. The second is currently being &#8216;tested&#8217; for Autism. There are no other family members that show signs of Autism in our side of the family, however, my brothers wife has family that have been diagnosed as such. </p>
<p>My wife and I are currently considering having children, whats the probability that we could have an autistic child? Is there any way to test for it? I may be being paranoid but its a concern I have. Any advice would be appreciated.</p>
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		<title>By: Like Father, Like Son: Chromosome 16 and susceptibility to autism</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-547536</link>
		<dc:creator>Like Father, Like Son: Chromosome 16 and susceptibility to autism</dc:creator>
		<pubDate>Thu, 10 Jan 2008 06:42:58 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-547536</guid>
		<description>[...] data from Children&#8217;s Hospital Boston and in a large population study in Iceland. [&#8221;De novo&#8221; refers to genetic mutations that are spontaneous and present in the child but not in his or [...]</description>
		<content:encoded><![CDATA[<p>[...] data from Children&#8217;s Hospital Boston and in a large population study in Iceland. [&#8221;De novo&#8221; refers to genetic mutations that are spontaneous and present in the child but not in his or [...]</p>
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		<title>By: Autism Vox at the Eden Institute Princeton Lecture Series</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-534616</link>
		<dc:creator>Autism Vox at the Eden Institute Princeton Lecture Series</dc:creator>
		<pubDate>Fri, 08 Jun 2007 17:43:48 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-534616</guid>
		<description>[...] 1.30pm.  Wigler spoke about &#8220;A Unified Genetic Theory for Sporadic and Inherited Autism.&#8221; A large proportion of genetic disorders, he noted, could be brought about by spontaneous [...]</description>
		<content:encoded><![CDATA[<p>[...] 1.30pm.  Wigler spoke about &#8220;A Unified Genetic Theory for Sporadic and Inherited Autism.&#8221; A large proportion of genetic disorders, he noted, could be brought about by spontaneous [...]</p>
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		<title>By: Kristina Chew, PhD</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-533676</link>
		<dc:creator>Kristina Chew, PhD</dc:creator>
		<pubDate>Tue, 24 Apr 2007 21:38:48 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-533676</guid>
		<description>John Timmer at &lt;a href=&quot;http://arstechnica.com/journals/science.ars/2007/04/24/spontaneous-gene-loss-may-produce-sporadic-autism&quot;&gt;Ars Technica&lt;/a&gt; has written a good summary of this study.</description>
		<content:encoded><![CDATA[<p>John Timmer at <a href="http://arstechnica.com/journals/science.ars/2007/04/24/spontaneous-gene-loss-may-produce-sporadic-autism">Ars Technica</a> has written a good summary of this study.</p>
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		<title>By: Autism Vox &#187; Autism and Controversy: Bring it on</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-532800</link>
		<dc:creator>Autism Vox &#187; Autism and Controversy: Bring it on</dc:creator>
		<pubDate>Thu, 05 Apr 2007 10:10:04 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-532800</guid>
		<description>[...] in Science Magazine, &#8220;found that the rate of mutations in certain genes is much higher is sporadic cases of autism (about 10 times the rate in healthy controls) compared to autism where there is a prior [...]</description>
		<content:encoded><![CDATA[<p>[...] in Science Magazine, &#8220;found that the rate of mutations in certain genes is much higher is sporadic cases of autism (about 10 times the rate in healthy controls) compared to autism where there is a prior [...]</p>
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		<title>By: Karen</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-532364</link>
		<dc:creator>Karen</dc:creator>
		<pubDate>Thu, 29 Mar 2007 19:06:13 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-532364</guid>
		<description>Lately I&#039;ve been thinking about my future children. I turn twenty on 4-4, so I&#039;ve been looking back at my teen years a lot, thinking about adulthood which still (thankfully) looms ahead.

I&#039;m really worried. I know that there&#039;s a high possibility that any child I have will have bad allergies, hyperthyroidism, even a higher chance of substance abuse (at least stretching back to great-grandparents on both sides, but especially my maternal lineage). But I worry *most* about autism.

It makes me feel really selfish, but I&#039;m aware enough to realize that I&#039;ve got problems socializing and empathizing with my peer group; I was a precocious child who didn&#039;t relate well to others, couldn&#039;t understand their fads.

Knowing these things about myself, I make myself work them through -- I work on making eye contact instead of focusing on mouths, I go to large gatherings when I&#039;d really rather go home and read a book or do a Sudoku puzzle. I know that I&#039;m normal, but I have a hyperawareness of my own social inabilities due, I think, to Scotty.

My brother&#039;s nonverbal, and he&#039;ll have to live with a family member his entire life. My grandparents are in ill health; within the next decade, decade &amp; a half, I think my sister &amp; I will have Scotty for ourselves. How&#039;re we going to do that? We&#039;re still young kids, so it&#039;s almost a distant future to us yet. My mother couldn&#039;t take him, our younger brother &amp; sister didn&#039;t grow up with us. We&#039;ll be alone in trying to help him.

It&#039;s scary, but it&#039;s more scary to think that, as a parent, I&#039;d have to worry about those things. It&#039;s scary to think that I&#039;d have a baby who&#039;d get the same teasing, have a little boy who couldn&#039;t go to church because he wouldn&#039;t be able to sit through mass, a frustrated little girl who couldn&#039;t tell us what was bothering her.

Or even a kid who had the same trouble socializing that I did -- it was horrible, absolute misery. I didn&#039;t like what they liked, I didn&#039;t speak how they spoke (I like the sound of words, and as a child, it was precise speaking, not slang, that appealed to me), I was rude without meaning to be, I didn&#039;t consider their feelings, and I corrected everybody, including teachers.

On one level, I think I&#039;m more prepared for it than someone who doesn&#039;t have an autistic sibling; on another, I worry that -- initially at least -- I&#039;ll have more resentment for the situation than someone with a &#039;clean slate.&#039;

Like I said, it makes me feel mean and selfish, but it&#039;s a long way off.</description>
		<content:encoded><![CDATA[<p>Lately I&#8217;ve been thinking about my future children. I turn twenty on 4-4, so I&#8217;ve been looking back at my teen years a lot, thinking about adulthood which still (thankfully) looms ahead.</p>
<p>I&#8217;m really worried. I know that there&#8217;s a high possibility that any child I have will have bad allergies, hyperthyroidism, even a higher chance of substance abuse (at least stretching back to great-grandparents on both sides, but especially my maternal lineage). But I worry *most* about autism.</p>
<p>It makes me feel really selfish, but I&#8217;m aware enough to realize that I&#8217;ve got problems socializing and empathizing with my peer group; I was a precocious child who didn&#8217;t relate well to others, couldn&#8217;t understand their fads.</p>
<p>Knowing these things about myself, I make myself work them through &#8212; I work on making eye contact instead of focusing on mouths, I go to large gatherings when I&#8217;d really rather go home and read a book or do a Sudoku puzzle. I know that I&#8217;m normal, but I have a hyperawareness of my own social inabilities due, I think, to Scotty.</p>
<p>My brother&#8217;s nonverbal, and he&#8217;ll have to live with a family member his entire life. My grandparents are in ill health; within the next decade, decade &amp; a half, I think my sister &amp; I will have Scotty for ourselves. How&#8217;re we going to do that? We&#8217;re still young kids, so it&#8217;s almost a distant future to us yet. My mother couldn&#8217;t take him, our younger brother &amp; sister didn&#8217;t grow up with us. We&#8217;ll be alone in trying to help him.</p>
<p>It&#8217;s scary, but it&#8217;s more scary to think that, as a parent, I&#8217;d have to worry about those things. It&#8217;s scary to think that I&#8217;d have a baby who&#8217;d get the same teasing, have a little boy who couldn&#8217;t go to church because he wouldn&#8217;t be able to sit through mass, a frustrated little girl who couldn&#8217;t tell us what was bothering her.</p>
<p>Or even a kid who had the same trouble socializing that I did &#8212; it was horrible, absolute misery. I didn&#8217;t like what they liked, I didn&#8217;t speak how they spoke (I like the sound of words, and as a child, it was precise speaking, not slang, that appealed to me), I was rude without meaning to be, I didn&#8217;t consider their feelings, and I corrected everybody, including teachers.</p>
<p>On one level, I think I&#8217;m more prepared for it than someone who doesn&#8217;t have an autistic sibling; on another, I worry that &#8212; initially at least &#8212; I&#8217;ll have more resentment for the situation than someone with a &#8216;clean slate.&#8217;</p>
<p>Like I said, it makes me feel mean and selfish, but it&#8217;s a long way off.</p>
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		<title>By: Genetics and Health &#187; Gene Genie Wonders About Spontaneous Mutations and Autism</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-532106</link>
		<dc:creator>Genetics and Health &#187; Gene Genie Wonders About Spontaneous Mutations and Autism</dc:creator>
		<pubDate>Tue, 20 Mar 2007 13:43:36 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-532106</guid>
		<description>[...] This morning, Genie is wondering how spontaneous deletions and duplications of DNA, aka copy number variation, scattered throughout the genome could be involved in autism spectrum disorders. Maybe they&#8217;re the result of some other injury that led to both autism and the mutations? Maybe it&#8217;s selection bias? The people in the study with autism must differ in other ways from healthy controls. Were all known and unknown factors controlled for? Genie reserves judgment until she knows more about what the biological importance of these hundreds of mutations. For more discussion, visit Kristina Chew at Autism Vox. [...]</description>
		<content:encoded><![CDATA[<p>[...] This morning, Genie is wondering how spontaneous deletions and duplications of DNA, aka copy number variation, scattered throughout the genome could be involved in autism spectrum disorders. Maybe they&#8217;re the result of some other injury that led to both autism and the mutations? Maybe it&#8217;s selection bias? The people in the study with autism must differ in other ways from healthy controls. Were all known and unknown factors controlled for? Genie reserves judgment until she knows more about what the biological importance of these hundreds of mutations. For more discussion, visit Kristina Chew at Autism Vox. [...]</p>
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		<title>By: Phil Schwarz</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-532092</link>
		<dc:creator>Phil Schwarz</dc:creator>
		<pubDate>Mon, 19 Mar 2007 04:05:26 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-532092</guid>
		<description>Kristina said:
&lt;blockquote&gt;I continue to be puzzled by the resistance of some in viewing autism as genetic.&lt;/blockquote&gt;

I think it&#039;s our community&#039;s analogue to a well-known archetype in the gay community: the virulent homophobe who is the way he (almost always a he) is because deep down inside he&#039;s afraid he might just be a little gay himself...</description>
		<content:encoded><![CDATA[<p>Kristina said:</p>
<blockquote><p>I continue to be puzzled by the resistance of some in viewing autism as genetic.</p></blockquote>
<p>I think it&#8217;s our community&#8217;s analogue to a well-known archetype in the gay community: the virulent homophobe who is the way he (almost always a he) is because deep down inside he&#8217;s afraid he might just be a little gay himself&#8230;</p>
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		<title>By: Kristina Chew, PhD</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-532057</link>
		<dc:creator>Kristina Chew, PhD</dc:creator>
		<pubDate>Sun, 18 Mar 2007 03:00:58 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-532057</guid>
		<description>Usal wrote: &lt;blockquote&gt;I also love my son the way he is, and I wouldn’t change him for anything. But on top of that I like myself the way I am and do not want to be made into someone else to make others happy. To quote a famous sailor “I am what I am.”&lt;/blockquote&gt;

Agree on both points (and agreeing with the sailor too--we&#039;ve a picture of Charlie and the statue of him in his creator&#039;s home town of Chester, IL). 

Haven&#039;t seen Gattaca, yet....</description>
		<content:encoded><![CDATA[<p>Usal wrote:<br />
<blockquote>I also love my son the way he is, and I wouldn’t change him for anything. But on top of that I like myself the way I am and do not want to be made into someone else to make others happy. To quote a famous sailor “I am what I am.”</p></blockquote>
<p>Agree on both points (and agreeing with the sailor too&#8211;we&#8217;ve a picture of Charlie and the statue of him in his creator&#8217;s home town of Chester, IL). </p>
<p>Haven&#8217;t seen Gattaca, yet&#8230;.</p>
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		<title>By: manju</title>
		<link>http://www.blisstree.com/articles/sporadic-and-heritable-autism/comment-page-1/#comment-532025</link>
		<dc:creator>manju</dc:creator>
		<pubDate>Sat, 17 Mar 2007 20:32:47 +0000</pubDate>
		<guid isPermaLink="false">http://www.autismvox.com/sporadic-and-heritable-autism/#comment-532025</guid>
		<description>Manju says:
  I agree with VAB that the study assumes autism to be genetic disorder and that autism is only a charecteristic manifested by a more complex cause and not entirely genetic, because what would explain the non genetic diseases associated with autism like presentation like congenital rubella syndrome.  It also runs in families with autoimmune disorders, not necessarily sporadic genetic disorders. I think this is &#039;survival of fittest&#039; that is, the these kids need to be unconnected socially as the world is heading into such an era where the people who are depedent on materialist world for work and pleasure survive  well. It seems true we moved from using our ears for listenig radio to using eyes to watch television.  The autistic trait we developed is passed on to our next generation be it an autistics&#039; strong feature.  
     In today&#039;s world of computers and video games and television entertainment which child has the inclination to go and improve social skill. Even responding to parents&#039; call becomes a rarerity as the child is constantly at these gadgets.  The evolution is preparing the future generation for this material world and we all will be extinct and might as well be compared to dinosaurs for talking about social interaction.</description>
		<content:encoded><![CDATA[<p>Manju says:<br />
  I agree with VAB that the study assumes autism to be genetic disorder and that autism is only a charecteristic manifested by a more complex cause and not entirely genetic, because what would explain the non genetic diseases associated with autism like presentation like congenital rubella syndrome.  It also runs in families with autoimmune disorders, not necessarily sporadic genetic disorders. I think this is &#8217;survival of fittest&#8217; that is, the these kids need to be unconnected socially as the world is heading into such an era where the people who are depedent on materialist world for work and pleasure survive  well. It seems true we moved from using our ears for listenig radio to using eyes to watch television.  The autistic trait we developed is passed on to our next generation be it an autistics&#8217; strong feature.<br />
     In today&#8217;s world of computers and video games and television entertainment which child has the inclination to go and improve social skill. Even responding to parents&#8217; call becomes a rarerity as the child is constantly at these gadgets.  The evolution is preparing the future generation for this material world and we all will be extinct and might as well be compared to dinosaurs for talking about social interaction.</p>
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