http://www.blisstree.com/articles/warfarin-sensitivity-and-the-vkorc1-gene/ Family, Health, Home and Lifestyles Tue, 15 Dec 2009 19:28:59 -0500 http://wordpress.org/?v=2.8.4 hourly 1 http://www.blisstree.com/articles/warfarin-sensitivity-and-the-vkorc1-gene/comment-page-1/#comment-567635 Genetics and Health » Warfarin Sensitivity DNA Test Wed, 15 Nov 2006 23:47:55 +0000 http://www.geneticsandhealth.com/?p=325#comment-567635 [...] Kimball Genetics, Inc. has launched the Warfarin Sensitivity DNA Test for routine clinical use early next year. It tests for variations in the CYP2C9 and VKORC1 genes which play a role in determining a person’s sensitivity to warfarin via metabolism and anticoagulation processes, respectively. Warfarin (brand name Coumadin) prevents blood clots is typically prescribed for patients who are experiencing irregular heartbeat or those who’ve had a heart attack or heart valve replace surgery. The Warfarin Sensitivity DNA Test that Kimball offers informs the prescriber about the presence of genetic risk factors for overanticoagulation and should help achieve the correct maintenance dose faster. It is also likely to increase the safety and efficacy of warfarin treatment. The DNA test identifies patients who are sensitive to warfarin and who therefore: 1) require a lower dose to achieve a target INR, 2) may be at an increased risk for bleeding complications, and 3) without the DNA test, would require a longer period of time to achieve stable warfarin dosing. [...] [...] Kimball Genetics, Inc. has launched the Warfarin Sensitivity DNA Test for routine clinical use early next year. It tests for variations in the CYP2C9 and VKORC1 genes which play a role in determining a person’s sensitivity to warfarin via metabolism and anticoagulation processes, respectively. Warfarin (brand name Coumadin) prevents blood clots is typically prescribed for patients who are experiencing irregular heartbeat or those who’ve had a heart attack or heart valve replace surgery. The Warfarin Sensitivity DNA Test that Kimball offers informs the prescriber about the presence of genetic risk factors for overanticoagulation and should help achieve the correct maintenance dose faster. It is also likely to increase the safety and efficacy of warfarin treatment. The DNA test identifies patients who are sensitive to warfarin and who therefore: 1) require a lower dose to achieve a target INR, 2) may be at an increased risk for bleeding complications, and 3) without the DNA test, would require a longer period of time to achieve stable warfarin dosing. [...]

]]> http://www.blisstree.com/articles/warfarin-sensitivity-and-the-vkorc1-gene/comment-page-1/#comment-567263 Genetics and Health » New Genetics and Health Poll: How much for your DNA sequence? Thu, 27 Jul 2006 10:43:37 +0000 http://www.geneticsandhealth.com/?p=325#comment-567263 [...] My thinking on this might be a little counterintuitive. At this point in time, our understanding of the impact specific genes have on our overall health is somewhat limited. We know that certain genes increase our risk of cancer, like BRCA or HNPCC, and that other genes might affect how we metabolize certain drugs. But beyond that, the majority of our DNA sequence doesn’t really tell us much yet. So I figure knowing our genomic sequence isn’t worth much now and prices (if it weren’t limited by technology) would be depressed. [...] [...] My thinking on this might be a little counterintuitive. At this point in time, our understanding of the impact specific genes have on our overall health is somewhat limited. We know that certain genes increase our risk of cancer, like BRCA or HNPCC, and that other genes might affect how we metabolize certain drugs. But beyond that, the majority of our DNA sequence doesn’t really tell us much yet. So I figure knowing our genomic sequence isn’t worth much now and prices (if it weren’t limited by technology) would be depressed. [...]

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