Blood pressure control is critically important for pregnant women and is a significant risk factor for preeclampsia. Up to now, angiotensin-converting enzyme (ACE) inhibitors have not been prescribed for women past their first trimester because they’re known to cause birth defects. A study of 29, 507 infants suggests that ACE inhibitors, such as captopril and lisinopril, may also cause birth defects in the first trimester as well. Birth defects resulting from ACE inhibitor use in later pregnancy include:

Bone abnormalities in the skull
Inhibition of growth
Fatal kidney damage