The most-aggressive form of Barrett’s esophagus is a precancerous condition that can lead to esophageal cancer.
The researchers also identified a cluster of four known cancer biomarkers, or genetic abnormalities, in people with Barrett’s that significantly increases their risk of developing esophageal cancer.
The risk of developing esophageal cancer in this patient population is significantly reduced by therapy with aspirin, ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs).
The researchers found that those with three or more of the cancer biomarkers upon enrollment in the study who also used aspirin or other NSAIDs had a 30 percent risk of esophageal cancer after 10 years, …read more

According to a new study published in the Journal of Biological Chemistry, a particular enzyme called NOX5-S is significantly higher in cancer cells that have been exposed to acid, leading to the overproduction of hydrogen peroxide: a possible explanation for how acid reflux may lead to cancer of the esophagus.
For the first time, researchers led by senior author Weibiao Cao (a researcher at Rhode Island Hospital and an assistant professor of medicine and surgery at Brown Medical School) have outlined the signaling pathway from cells damaged by acid, to the progression of esophageal cancer.
The researchers believe that this very same …read more