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Gene signature found for breast cancer survival

April 23, 2008 by Elaine  
Filed under Health

Gene signature found for breast cancer survival

(Photo: Breast cancer cell , courtesy www.hopeforcancer.com)
Scientists believe they have identified a gene that may be able to limit the growth of breast cancer tumors.
The US National Cancer Institute, led by geneticist Kent Hunter found in tests on mice that tumors containing the bromodomain 4  or Brd4 gene ended up 10 times smaller than ones that did not.
In typically growing cells, Brd4 is a nuclear protein that’s associated with chromatin. It apparently influences DNA replication and cell cycle progression. Because of its previously identified physical interaction with an invasiveness-suppressing GTPase activating protein called Sipa1, Hunter and his colleagues decided to delve into …read more


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