GIP is a hormone that is secreted in response to your food intake . It inhibits the secretion of acids that stimulate the release of insulin as part of the digestive process thus Pro3(GIP) combating this.

While the significance of its action is largely unknown, its potent and prolonged stimulation after a high-fat diet has led researchers to speculate it may play a key role in metabolizing fat. Research has shown that high fat feeding results in elevated circulating GIP concentrations, traits often found in patients who are obese with diabetes. GIP also effects the growth of fat cells. Other studies have shown that mice injected with the GIP receptor antagonist – (Pro3)GIP – can reverse or prevent many of the metabolic abnormalities associated with obesity.

So, in a nutshell… more GIP bad, less GIP good! That was easy, haha. And just what did they find with this particular study?

This study showed that blocking GIP activity using (Pro3)GIP in mice with established, high fat diet-induced obesity and diabetes results in significant weight loss, improvement of insulin resistance and amelioration of diabetes.

Researchers are now examining the findings as an interesting new way to battle obesity and metabolic disorders.

Post from: Blisstree

Pro3(GIP) To Promote Weight Loss, Improve Insulin Resistance And Reverse Diabetes

Some of you might have already seen the article and read through it but for those that didn’t, I’m going to share. The story is about a Chicago first grader Lilly Jaffe who has been diabetic since she was one month old and her trials, complications and use of an insulin pump. At this point in her very young and full life Lilly does not need any insulin or pumps anymore, she takes pills to control her diabetes and is living a very active life. Um huh, I said pills!

After years of uncontrolled blood sugars and her father attending a conference, doctors discovered that Lilly had what they call “sleeping” insulin producing cells, which is marked on your insulin gene and can be stimulated by a drug that has been safely used in adults for years… sulphonylurea.

Sulphonylurea works on the beta cells of the pancreas to increase the secretion of insulin. And viola, success! Lilly now plays soccer, dances her heart out at ballet class and even has sleepovers with her girlfriends. Her father calls it a “miracle”.

via People magazine, December the 24th, 2007

Post from: Blisstree

Trading In An Insulin Pump For The Drug Sulphonylurea