Not only has it been shown to have potentials in reducing cancer risks, Vitamin D also appears to control the body’s innate immune response, affecting a skin wound’s ability to heal. It appears to play an important role in the body’s ability to produce cathelicidin, a compound produced by wounds and is necessary to fight infections.
Gallo’s team has now discovered that injury stimulates skin cells called keratinocytes, which surround the wound, to increase the production of vitamin D3 and that this in turn increases the expression of genes (CD14 and TLR2) that detect microbes. These genes, together with active vitamin …read more